Excess weight and obesity often seem stubbornly resistant to traditional weight loss strategies due to altered metabolism. This metabolic shift impairs the breakdown of stored fats into energy, making weight loss challenging. This is where understanding the role of an enzyme called NNMT becomes crucial.
NNMT & Weight Gain
As fat cells grow larger, they produce more NNMT, a key enzyme that slows down fat metabolism. This slowdown makes it difficult for fat cells to burn accumulated fat, leading to weight gain and contributing to chronic diseases like type 2 diabetes and cardiovascular issues.
Researchers at the University of Texas made a groundbreaking discovery: they identified a molecule that counteracts NNMT's metabolic slowdown in white fat cells. Blocking NNMT's effects boosted fat cell metabolism and reduced the size of white fat deposits, addressing a root cause of obesity and related diseases.
NNMT: The Cellular Culprit
Nicotinamide N-methyltransferase (NNMT) plays a pivotal role in cellular energy balance. It regulates molecules within pathways governing cellular energy. When NNMT is overactive, it initiates a chain reaction: increased NNMT leads to poor fat cell metabolism, which then results in expanded fat cell mass and weight gain.
Reversing the Domino Effect: NNMT and Weight Loss
Reducing NNMT yields multiple benefits for weight loss. Firstly, decreased NNMT curbs fat cell growth. Secondly, it corrects fat cell metabolism. Thirdly, it leads to weight loss as fat cells shrink.
Blocking Metabolic Slowdown for Weight Loss
To inhibit NNMT and trigger weight loss, researchers experimented with variations of methyl quinolinium (MQ). Out of all the variations of MQ studied, 5-amino 1MQ came out on top as the most effective. 5-amino 1MQ is a small, selective membrane permeable molecule that blocks the NNMT enzyme. What made it even more effective is that it did not affect the activity of any other enzymes in the metabolic cycles, which reduced the risks of any potential side effects. This breakthrough holds potential for addressing obesity and related conditions, while also offering promise in managing various diseases linked to NNMT.
5-Amino 1MQ: A Multi-Benefit Solution
This molecule offers more than just weight loss. It has the potential to reverse diet-induced obesity, treat metabolic conditions, enhance cellular energy regulation, prevent fat accumulation, and positively influence cellular energy balance.
Understanding NNMT's role in the body's complex mechanisms sheds light on new avenues for combating obesity and related health challenges. It’s important to consult a healthcare professional before considering any treatments.
Benefits of 5-amino 1MQ
- Can reverse diet-induced obesity
- Can treat related metabolic conditions
- Can increase cellular energy regulators
- Can prevent lipogenesis (fat accumulation)
- Can increase NAD+and SAM concentrations in fat cells
- Can regulate energy expenditure in fat cells
To purchase 5-Amino 1MQ please call our office: 480-839-4131
Neelakantan H, Vance V, Wetzel MD, Wang H-YL, McHardy SF, Finnerty CC, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology. 2018;147(Supplement C):141-52.
Pissios P. Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme. Trends in Endocrinology & Metabolism. 2017;28(5):340-53.
Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. NicotinamideN-methyltransferase knockdown protects against diet-induced obesity. Nature. 508(7495):258–262, APRIL 10TH, 2014
Neelakantan H, Vance V, Wang HY, McHardy SF, Watowich SJ. Non-coupled fluorescent assay for direct real-time monitoring of nicotinamide N-methyltransferase activity. Biochem. 56, 824, 2017.
Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Structure–activity relationship for small molecule inhibitors of nicotinamide N- methyltransferase. J. Med. Chem. 60, 5015, 2017.