Mechano Growth Factor, or MGF, is a peptide derived from a different sequence of insulin-like growth factor-1 (IGF-1), which plays a large role in childhood development and continues to have anabolic effects throughout adulthood. MGF (Mechano Growth Factor) is released in response to muscles being stretched and exercised. This is particularly abundant when a muscle has been exposed to high-intensity weight training.
MGF has the ability to encourage repair and growth of wasted tissue through the activation of muscle stem cells, thereby increasing the synthesis of proteins necessary for tissue growth. This peptide is ideal for anyone suffering from muscle loss, either due to old age or a particular condition.
Benefits of MGF:
- Activates muscle satellite stem cells
- Triggers fusion of ‘satellite’ stems cells to the muscle fibers.
- Satellite cells provide additional nuclei required for repair
- Essential for recovery, repair, and growth of new cells
How MGF works:
IGF-I is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is involved in the activation of muscle satellite (stem) cells. These donate nuclei to the muscle fibers that are required for repair and for the hypertrophy process, which may have similar regulatory mechanisms (Goldspink, G., 2005 p22). MGF is essential for repair and therefore growth of new cells, similar to IGF-1. If MGF is not PEGylated, the half-life is several minutes, therefore, PEGylated MGF must be considered during the compounding process to ensure an appropriate half-life, thereby increasing the duration of action.