Stress in Gastrointestinal Tract and Stable Gastric Pentadecapeptide BPC 157. Finally, do we have a Solution? Predrag Sikiric, Sven Seiwerth, Rudolf Rucman, Domagoj Drmic, Mirjana Stupnisek, Antonio Kokot, Marko Sever, Ivan Zoricic, Zoran Zoricic, Lovorka Batelja, Tihomil Ziger, Kresimir Luetic, Josipa Vlainic, Zarko Rasic, Martina Lovric Bencic. Current Pharmaceutical Design. Volume 23 , Issue 27 , 2017BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Research has shown BPC-157 to have considerable biological healing properties. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including tendons, muscles, nervous system and superior healing of damaged ligaments. This peptide can be very useful to athletes or just the average person who has daily aches, pains or injury. Overuse of our body can cause muscle, tendon and ligament issues that affect our everyday life. The addition of BPC-157 can help heal those everyday aches and pains.
Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. It can also help aid skin burns to heal at a faster rate and increase blood flow to damaged tissues.
Benefits of BPC 157:
- Accelerated wound healing (muscle, ligament, tendon, nerve)
- Has been shown to decrease pain in damaged areas
- BPC 157 increases growth hormone receptors
- Promotes the outgrowth of tendon fibroblasts, cell survival under stress, and the migration of tendon fibroblasts
- Improves digestive function
- May improve blood pressure and NO production
- Protects and heals inflamed intestinal epithelium (leaky gut)
- It has also been shown to help in Inflammatory bowel disease
- Protects liver from toxic insults (alcohol, antibiotics, etc) and promotes healing
- In tendons, BPC-157 increases fibroblast growth via phosphorylation levels of both FAK and paxillin (dose dependently)
- In collagen repair, BPC-157 stimulates EGR-1 which induces cytokine and growth factor generation and early extracellular matrix (collagen) formation
- EGR-1 also increases its co-repressors such as nerve growth factor 1-A binding protein-2 (NAB2)
- BPC-157 can increase decrease B4 (LTB4), thromboxane B2 (TXB2), and myeloperoxidase (MPO) in the serum and inflamed tissues and increase macrophages activity
Stable gastric pentadecapeptide BPC 157 is an antiulcer peptidergic agent, safe in inflammatory bowel disease clinical trials and wound healing, stable in human gastric juice and has no reported toxicity. Notably, it has a prominent effect on alcohol lesions (i.e., acute, chronic) and NSAIDs-lesions (interestingly, BPC 157 both prevents and reverses arthritis)… and acts as a free radical scavenger and exhibits neuroprotective properties.
(Sikiric, P., et al., Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract. CPD, 2011. 17(16): p. 1612-1632.)
Molecules. 2014 Nov 19;19(11):19066-77. doi: 10.3390/molecules191119066. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Chang CH1, Tsai WC2, Hsu YH3, Pang JH4.
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Chung-Hsun Chang, Wen-Chung Tsai, Miao-Sui Lin, Ya-Hui Hsu, and Jong-Hwei Su Pang. 01 MAR 2011https://doi.org/10.1152/japplphysiol.00945.2010
Curr Pharm Des. 2013;19(1):76-83. Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157. Sikiric P1, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Aralica G, Safic H, Suran J, Rak D, Dzidic S, Vrcic H, Sebecic B.
Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Danira Pevec, Tomislav Novinscak, Luka Brcic, Kristijan Sipos, Ivana Jukic, Mario Staresinic, Sandro Mise, Iva Brcic, Danijela Kolenc, Robert Klicek, Tihomir Banic, Marko Sever, Ana Kocijan, Lidija Berkopic, Bozo Radic, Gojko Buljat, Tomislav Anic, Ivan Zoricic, Ivan Bojanic, Sven Seiwerth, Predrag Sikiric. Med Sci Monit 2010; 16(3): BR81-88 ID: 878454 Published: 2010-02-26
Eur J Pharmacol. 1999 Aug 20;379(1):19-31. Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats. Jelovac N1, Sikiric P, Rucman R, Petek M, Marovic A, Perovic D, Seiwerth S, Mise S, Turkovic B, Dodig G, Miklic P, Buljat G, Prkacin I
J Orthop Res. 2010 Sep;28(9):1155-61. doi: 10.1002/jor.21107. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. Cerovecki T1, Bojanic I, Brcic L, Radic B, Vukoja I, Seiwerth S, Sikiric P
J Orthop Res. 2006 May;24(5):1109-17. Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157. Staresinic M1, Petrovic I, Novinscak T, Jukic I, Pevec D, Suknaic S, Kokic N, Batelja L, Brcic L, Boban-Blagaic A, Zoric Z, Ivanovic D, Ajduk M, Sebecic B, Patrlj L, Sosa T, Buljat G, Anic T, Seiwerth S, Sikiric P
Stress in Gastrointestinal Tract and Stable Gastric Pentadecapeptide BPC 157. Finally, do we have a Solution? Predrag Sikiric, Sven Seiwerth, Rudolf Rucman, Domagoj Drmic, Mirjana Stupnisek, Antonio Kokot, Marko Sever, Ivan Zoricic, Zoran Zoricic, Lovorka Batelja, Tihomil Ziger, Kresimir Luetic, Josipa Vlainic, Zarko Rasic, Martina Lovric Bencic. Current Pharmaceutical Design. Volume 23 , Issue 27 , 2017
J Physiol Pharmacol. 2009 Dec;60 Suppl 7:191-6. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Brcic L1, Brcic I, Staresinic M, Novinscak T, Sikiric P, Seiwerth S
Regul Pept. 2010 Feb 25;160(1-3):33-41. doi: 10.1016/j.regpep.2009.11.005. Epub 2009 Nov 10. Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury. Gjurasin M1, Miklic P, Zupancic B, Perovic D, Zarkovic K, Brcic L, Kolenc D, Radic B, Seiwerth S, Sikiric P.
Curr Med Chem. 2012;19(1):126-32. Focus on ulcerative colitis: stable gastric pentadecapeptide BPC 157. Sikiric P1, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Stambolija V, Zoricic Z, Vrcic H, Sebecic B.
Eur J Pharmacol. 2007 Sep 10;570(1-3):212-21. Epub 2007 Jun 16. Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. Tkalcević VI1, Cuzić S, Brajsa K, Mildner B, Bokulić A, Situm K, Perović D, Glojnarić I, Parnham MJ
Stable Gastric Pentadecapeptide BPC 157-NO-system Relation. Predrag Sikiric, Sven Seiwerth, Rudolf Rucman, Branko Turkovic, Dinko Stancic Rokotov, Luka Brcic,Marko Sever, Robert Klicek, Bozo Radic, Domagoj Drmic, Spomenko Ilic, Danijela Kolenc, Gorana Aralica, Mirjana Stupnisek, Jelena Suran, Ivan Barisic, Senka Dzidic, Hrvoje Vrcic, Bozidar Sebecic. Current Pharmaceutical Design. Volume 20 , Issue 7 , 2014