GHK-CU FOR HAIR AND SKIN

GHK-Cu is a naturally occurring copper complex first identified in human plasma but recently found in multiple locations, such as saliva and urine.

GHK-Cu has a variety of roles in the human body, including promoting activation of wound healing, attracting immune cells, having anti-oxidant and anti-inflammatory effects, stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, and promoting blood vessel growth.

Evidence has shown that it acts as a feedback signal generated after tissue injury. It seems to act as a potent protector of tissue, and it is an anti-inflammatory agent that controls the oxidative damage that occurs after tissue injury. Further, it then plays a big role in signaling tissue remodeling, removing damaged/scarred tissue and generating new, healthy tissue.

These positive effects decline with age because the concentration of GHK-Cu in the body decreases.

Benefits of GHK-Cu

Here are some key benefits of copper peptide GHK-Cu.

Tightens loose skin and reverses thinning of aged skin
Repairs protective skin barrier proteins
Improves skin firmness, elasticity, and clarity
Reduces fine lines and depth of wrinkles and improves the structure of aged skin
Smooths rough skin
Reduces photodamage, mottled hyperpigmentation, skin spots, and lesions
Improves overall skin appearance
Stimulates wound healing
Protects skin cells from UV radiation
Reduces inflammation and free radical damage
Increases hair growth and thickness; enlarges hair follicle size

GHK-Cu Research

Since GHK-Cu plays an important role in skin biology, it is widely used in cosmetics as a reparative and anti-aging ingredient.

GHK stimulates the synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity of both metalloproteinases and their inhibitors. It stimulates collagen, dermatan sulfate, chondroitin sulfate, and the small proteoglycan decorin. It also restores replicative vitality to fibroblasts after radiation therapy. The molecule attracts immune and endothelial cells to the site of an injury. It accelerates wound healing of the skin, hair follicles, gastrointestinal tract, and boney tissue. In cosmetic products, it has been found to tighten loose skin and improve elasticity, skin density, and firmness, reduce fine lines and wrinkles, reduce photodamage and hyperpigmentation, and increase keratinocyte proliferation.

GHK-Cu FACIAL STUDIES

Copper peptide GHK-Cu is widely used in anti-aging cosmetics (INCI name: Copper tripeptide-1). Several controlled facial studies confirmed the anti-aging, firming and anti-wrinkle activity of copper peptide GHK-Cu. Abdulghani et al. established that facial cream containing GHK-Cu increased collagen in photoaged skin of 20 female volunteers, performing better than vitamin C and retinoic acid. Leyden et al. conducted 12 weeks facial study of GHK-Cu containing face and eye cream, reporting significant improvement of skin laxity, clarity, and appearance, reduced fine lines and the depths of wrinkles, and increased skin density and thickness compared to placebo. GHK-Cu eye cream performed better than vitamin K cream. Finkley et al. conducted a 12-week facial study on 67 women and reported that GHK-Cu cream applied twice daily improved aged skin appearance, increased thickness, reduced wrinkles and strongly stimulated dermal keratinocyte proliferation as determined by histological analysis of biopsies. The same study found copper peptide GHK-Cu to be non-toxic and non-irritating.

HAIR GROWTH BENEFITS OF GHK-CU

Copper peptide GHK-Cu and its analogs were found to strongly stimulate hair growth. The efficiency of the synthetic analog of GHK-Cu was similar to that of 5% minoxidil.

Conclusion

GHK-Cu can promote activation of wound recovery, appeal of immune cells, antioxidant, and anti-inflammatory consequences, stimulation of collagen and glycosaminoglycan synthesis in pores and skin fibroblasts and merchandising of blood vessels increase.

GHK is a safe, extensively studied compound that has a wealth of positive and health-promoting effects in many tissues and systems. It has been widely used in anti-aging and cosmetic products in humans for decades without any adverse effects and can be easily incorporated in creams, liposomes, foams or subcutaneous injections.

Other Hair & Skin Peptides:

Research References:

Abdulghani, AA, Sherr S, Shirin S, Solodkina G, Tapia EM, Gottlieb AB. Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study. Disease Manag Clin Outcomes. 1998;1:136-141
Leyden J, Stephens T, Finkey MB, Appa, Y, Barkovic S, Skin Care Benefits of Copper Peptide Containing Facial Cream. Amer Academy Dermat Meeting, February 2002, Abstract P68, P69
Finkley MB, Appa Y, Bhandarkar S. Copper Peptide and Skin. Cosmeceuticals and Active Cosmetic, 2nd Edition, P. Eisner and H.I. Maibach (Eds.) Marcel Dekker, New York. 2005:549-563
Gorouhi, Farzam, and Howard I. Maibach. "Topical peptides and proteins for aging skin." Textbook of Aging Skin. Springer Berlin Heidelberg, 2010. 1089-1117.
Pickart, Loren, Jessica Michelle Vasquez-Soltero, and Anna Margolina. "GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration." BioMed research international 2015 (2015).
Pickart, Loren, Jessica Michelle Vasquez-Soltero, and Anna Margolina. "The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health." Oxidative medicine and cellular longevity 2012 (2012)
Pickart L. The human tri-peptide GHK and tissue remodeling". J. Biomater. Sci. Polymer Edn. 2008; 19(8):969-988 Peptide Sequence: Gly-His-Lys(Cu2+)