Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin, which is naturally produced in the pineal gland.
This polypeptide is initially produced in the pineal gland. The scientist Professor Vladimir Khavinson discovered Epitalon, and over the following 35 years, he conducted extensive research involving both animal and human clinical trials.
The main purpose of Epitalon is to boost the production of telomerase, a natural enzyme responsible for the replication of telomeres, the protective sections of our DNA. Telomeres play a crucial role in DNA replication, allowing the body to generate new cells and renew old ones.
In our youth, telomerase production is relatively high, resulting in longer telomeres, which contribute to robust cell health and replication. However, as we age, telomerase production diminishes, leading to decreased cell health and replication efficiency.
Beyond its impact on telomeres, Epitalon also influences other aspects of bodily function. It contributes to metabolic regulation, enhances the sensitivity of the hypothalamus to its natural hormonal signals, balances the anterior pituitary's function, and regulates gonadotropin and melatonin levels within the body.
Benefits of Epitalon
As a result of Epitalon’s effect on telomerase production, the benefits are unique and far-reaching and include:
- Increases lifespan by lengthening telomeres in human cells
- Promotes deeper sleep
- Delays and prevents of age-related diseases such as cancer, heart disease, and dementia
- Acts as an antioxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function
- Improves skin health and appearance
- Heals injured and deteriorating muscle cells
- Restores and normalizes melatonin levels in those who have lost some pineal function due to aging
- Can increase resistance to emotional stress
Conclusion
Epitalon offers a number of benefits that can help combat the symptoms of aging. It also helps with mood, and acts as an antioxidant.
Numerous studies have shown the importance of telomerase production and telomere rejuvenation in fighting the symptoms of aging. As Epitalon has been shown to increase the production of telomerase, which in turn strengthens and lengthens telomeres, this means that Epitalon can play a vital role in decreasing the aging process and thus extend human longevity.
Research:
- Anisimov, V.N., Khavinson, V.K. (2009). The use of peptide bioregulators for cancer prevention: results of 35 years of research experience and perspectives. Voprosy Onkologii [Russia]. 55(3):291-304.
- Khavinson VKh, Bondaev IE, Butyugov AA, Smirnova TG. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004 May;137(5):503-6.
- Bartsch, C. & Bartsch, H. (2000). Pineal gland and cancer – An epigenetic approach to the control of malignancy: Evaluation of the role of melatonin. Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-.
- Christensen, K., Thinggaarda, M., McGue, M., Rexbye, H., Hjelmborg, J.B., Aviv, A., … Vaupel, J.W. (2009). Perceived age as a clinically useful biomarker of aging: cohort study. Bio Medical Journal (online). 339:b5262.
- Dilman, V. M., Dean, W., Fowkes, S. W., & Dilman, V. M. (1992). The neuroendocrine theory of aging and degenerative disease.Pensacola, FL: Center for Bio-Gerontology.
- Khavinson., V.K. (2002). Peptides and aging. Neuroendocrinology Letters [ special issue]. p. 144.
- Khavinson, V.K., Bondarev, E., Butyugov, A.A. (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulleting of Experimental Builogy and Medicine. 135(6): 590-592.
- Khavinson, V.K., & Morozov, V. (2003). Peptides of pineal gland and thymus prolong human life. Neuroendocrinology Letters. 24:233-240.
- Korkushko, O.V., Khavinson, V.K., Shatilo, V.B., Magdich, L.V. (2004). Effect of peptide preparation epithalamin on circadian rhythm on epiphyseal melatonin-producing function in elderly people. Bulletin of Experimental Biology and Medicine [Russia]. 137(4): 127-146.
- Labunets., I.F., Butenko, G.M., Magdich, L.V., Korkushko, O.V., Khavinson, V.K., Shatilo, V.B. (2004). Effect of epithalamin on circadian relationship between the endocrine function of the thymus and melatonin-producing function of the pineal gland in elderly people. Bulletin of Experimental and Biological Medicine [Russia]. 137(5):617-619.
- Terry, D.F., Nolan, V.G., Andersen, S.L., Perls, T.T., Cawthon, R. (2008). Association of longer telomeres with better health in centenarians. The Journals of Gerontology Series A, Biological and Medical Sciences. 63(8): 809-812.
