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synaptic-plasticity copy

Our brain contains trillions of neuronal connections. These connections are called synapses and their pattern of activity controls all our cognitive functions. These synaptic connections are constantly changing in their strength and activity level. This is known as “synaptic plasticity” and it’s essential for learning and memory. Synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity.

Poor memory and cognitive deficits, such as autism and Alzheimer's disease are thought to be due to changes in synaptic plasticity mechanisms.  Studies show that synapses can be made more plastic using a small peptide made from a neuronal protein involved in cell-to-cell communication. This peptide is called FGL (Fibroblast Growth Factor).

What is FGL?

FGL is a peptide derived from the neural cell adhesion molecule (NCAM). NCAM is a glycoprotein that is found on the surface of nerve cells (neurons) and glial cells (protect neurons). NCAM activates FGL which in turn stimulates the production of new projections of developing neurons.

FGL also plays a role in the formation of synapses between neurons which results in improved synaptic plasticity and neuronal development. This in combination with enhanced synaptic transmission means FGL can help encode information, resulting in improved learning and memory. Add in neuronal cell protection and preservation and FGL becomes an important peptide with the potential to treat multiple conditions affecting cognitive function.

Potential Benefits

Using the FGL peptide can result in these potential benefits:

  • Neuroprotective benefits 
  • Improved cognitive function
  • Treatment for traumatic brain injury
  • Protection against neurotoxicity
  • Improved memory
  • Improved learning
  • Treatment for cognitive decline (Alzheimer’s)
  • Improvements in neuroinflammation
  • Antidepressant features
  • Enhance Excitatory Synaptic Transmission

FGL Dosing 

FGL comes in the form of a nasal spray which is administered daily.


FGL has been shown to improve the brain's ability to modify the connections between neurons, the cellular building blocks of the brain.  Many neuroscientists consider understanding plasticity the Holy Grail for learning and memory. Once we understand it, we will understand how the brain learns.

In addition to its effects on neurodegenerative disease, FGL is viewed as a targeted treatment for traumatic brain injury (TBI), memory enhancement, strokes, depression, and general improvement of cognitive function.

FGL’s potential effect on memory and neurodegenerative disease progression have excited many researchers. In 2016, a 60 million dollar grant was awarded for further studies and exploration.

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