Ipamorelin is one of the latest and greatest peptides in the growth factor family. Deemed one of the safest GHRP's, Ipamorelin is a selective growth hormone (GH) Secretagogue and Ghrelin receptor agonist. Ipamorelin is a 3rd generation GHRP, regarded as the cleanest of the GHRP's. Ipamorelin stands out due to its enhanced specificity. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated. The strength is comparable to GHRP-6 and GHRp-2.
Gland Stimulated: Pituitary Gland
Benefits of Ipamorelin:
- Decreased body fat
- Increased collagen production
- Increased lean muscle mass
- Improved sleep
- Increased cellular repair and & Regeneration
- Increased IGF-1
- Increases bone mineral content
- Counteracts glucocorticoid catabolic effects
- Less appetite stimulation than GHRP-6
- Less release of cortisol, prolactin, and aldosterone
Ipamorelin has been shown to be both highly potent and very selective in vivo and vitro situations and has also demonstrated good safety and tolerability in human clinical studies. Research has shown that Ipamorelin is growth hormone specific which means that the pituitary hormones such as cortisol are unaffected. Though it is turning out that Ipamorelin may be one of the best alternatives available to HGH therapy, as it not only promotes the extra production of the subjects own GH and, additionally, helps to stimulate the liver to produce greater amounts of IGF-1 in the process but it’s also understood to not influence certain bodily processes to happen, unlike other secretagogues that have been shown to function in a similar capacity.
One very important point for patients participating in other secretagogue therapies is that it has been determined that it does not promote increased production of the enzyme ghrelin. Keep in mind that the secretion of ghrelin is mainly just a means to stimulate hunger. However, the benefits of Ipamorelin has been determined to not cause this increase due to its ability to control points of gastric, appetite, and growth motility.
Another very significant positive difference is that Ipamorelin does not display a capacity to significantly boost levels of cortisol. Research has shown that Ipamorelin is growth hormone specific which means that the pituitary hormones are also unaffected. Patients on different types of secretagogue therapies have reported jitters, cold sweats or nervousness and this is due to those other therapy’s overall impact on cortisol levels. Because benefits of Ipamorelin does not affect the body in this way, patients are able to better benefit from just the positive aspects of GH therapy, while keeping unwanted side effects at bay.
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