Recover faster with peptide therapy! Here are 3 game changing peptides shown to help aid in recovery post injury or surgery!
Insulin-like growth factor-I (IGF-I) plays an important role in muscle regeneration. It can reduce age-related loss of muscle function and cause muscle hypertrophy (growth) when over-expressed. These effects are due to promoting growth and differentiation of satellite cells as well as recruiting bone marrow stem cells to regions of damaged muscle tissue.
We know that IGF-I and growth hormone (GH) are involved in a large variety of physiologic functions in the body. They are also known to promote healing and repair in bone, cartilage, gastric ulcers, muscle, skin, ligaments, and tendons. GH and IGF-I directly affect the cells involved in the healing response. Insulin-like growth factor-I also stimulates fibroblast synthesis of extracellular matrix (ECM) molecules such as proteoglycans and type I collagen.
All studies demonstrated a positive association between IGF-I and wound healing. IGF-I promoted the migration of keratinocytes which play an important role in wound epithelialization as well as enabling wound bed contraction. It also stimulated hyaluronan, a key player in the tissue regeneration process. The wound healing-promoting effect of IGF-I may be a great asset in dealing with the healing of challenging wounds
Several other studies have shown that IGF-I contributes to the repair of a variety of tissues including repair of skeletal muscle tissue and myocardial tissue.
It’s easy to see the many benefits of Insulin-like Growth Factor 1. It facilitates protein synthesis, increases regenerative properties of the body’s tissues, upregulates anti-oxidant benefits and ligament strength and boosts hyperplasia in muscle cells.
Thymosin Beta-4 and TB500 are in essence, functionally, the same. TB500 is a synthetic fragment of that protein, and it is responsible for targeted tissue healing in muscles and connective tissue. This cell building protein is an essential component of cell structure and movement which leads to its role in tissue repair. TB500 has been found to play an important role in protection, regeneration and remodeling of injured or damaged tissues.
One of the main mechanisms of action of TB500 is its regulation of Actin. The ability to upregulate this cell building protein contributes to forming the contractile filaments of muscle cells. Upregulating actin allows TB500 to promote healing, cell growth, cell migration and cell proliferation. This helps build and create new blood vessel pathways and at the same time promoting the good type of inflammation that is directly responsible for faster wound healing.
The primary driver of blood vessel growth is a hormone called vascular endothelial growth factor (VEGF for short). TB 500 directly increases the production of VEGF. A robust supply of blood vessels is necessary to deliver immune and repair cells to a site of injury. Research shows that responsive blood vessel growth is necessary for all types of wound repair including musculoskeletal, cardiovascular, and neurological injuries.
Because of its low molecular weight, TB-500 is very versatile, mobile and possesses the ability to travel to the site of injury. Targeting injured areas enhances healing, tissue repair and the growth of new blood cells in damaged tissue. At the same time TB500 prevents the formation of adhesions and fibrous bands in muscles, tendons, and ligaments.
Research has shown that BPC-157 to have considerable biological healing properties. BPC 157, a derivative of body protection compound (BPC), affects the growth and migration of fibroblasts, the cells responsible for extracellular matrix repair.
Studies of healing tendons show increased levels of bFGF, EFG, and VEGF following the administration of BPC 157. A wound will heal faster when exposed to higher levels of these growth factors. BPC 157 also works on growth hormone (GH) receptors. Evidence from in vivo experiments show that BPC 157 dramatically increases the numbers of GH receptors on tendons. We know that Growth hormone can speed up wound healing and increase musculoskeletal development.
The formation of new blood vessels is a process called angiogenic repair. This results in more oxygen and energy being delivered to the injured area which promotes faster recovery. As mentioned above, the primary driver of blood vessel growth is a hormone called vascular endothelial growth factor. We know that TB 500 directly increases the production of VEGF. BPC 157 compliments this by increasing the number of available VEGF receptors. Both peptides help stimulate the growth of new blood vessels in slightly different ways.
It can accelerate wound healing (muscle, ligament, tendon, nerve), decrease inflammation, decrease pain, increase growth hormone receptors and promote new tendon fibroblast growth. BPC 157 can accelerate the healing of almost any injury – internal or external. It is an important piece of the post-injury treatment protocol and should be considered in the recovery from any post-surgical procedure or injury.
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