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Diethylpropion (Tenuate) is an appetite suppressant that has been effective in helping people lose weight. It is designed to be used in combination with a healthy diet and regular exercise. Losing weight and maintaining it can reduce the health risks associated with obesity, including heart disease, diabetes, and high blood pressure.

Benefits of Diethylpropion

Diethylpropion offers several benefits in supporting weight loss efforts and reducing health risks associated with obesity.

Diethylpropion acts as an effective aid in weight loss. By decreasing appetite, it helps individuals control their food intake, reduce cravings, and prevent binge eating. This appetite suppressant property makes it a valuable tool in the initial phases of a weight loss regimen. However, it is important to note that Diethylpropion is not a simple or quick fix for weight management. It is intended to be used in combination with a healthier nutrition plan and lifestyle habits.

Achieving and maintaining a healthy weight significantly reduces the risks of developing various health conditions associated with obesity. By effectively managing weight through the use of Diethylpropion, individuals can decrease the chances of experiencing heart disease, diabetes, high blood pressure, and other obesity-related health issues.

Diethylpropion is a Central Nervous System stimulant that helps increase patient energy levels. This increased energy can be harnessed and expended through regular exercise, further contributing to weight loss efforts and overall well-being.

Diethylpropion and Phentermine: How They Differ

While both Diethylpropion and Phentermine are appetite suppressants and share similar side effects, they have distinct chemical compositions. Consequently, individuals may experience varying reactions to each medication. In cases where patients encounter side effects that make continued use of one drug impossible or where one drug is not yielding desired results, they may explore the alternative treatment option of the other drug.

How Diethylpropion Works

Diethylpropion works by affecting parts of the central nervous system to suppress the feeling of hunger. It stimulates the hypothalamus gland, which plays a crucial role in regulating sleep cycles, body temperature, appetite, and more. By influencing certain neurotransmitters, Diethylpropion helps decrease the sensation of hunger. Additionally, it is known to increase energy levels.

Forms of Diethylpropion

Immediate-Release 25mg

  • Dosage instructions: Take up to three times a day, one hour before meals or as directed by your physician.
  • Timing and considerations: If late-night eating is an issue, an additional dose may be required in the evening. Taking this medication late in the day may cause insomnia.

Extended-Release 75mg

  • Dosage instructions: Usually taken once a day in the morning.
  • Administration precautions: Do not crush or chew the extended-release tablets, as it can release the entire dose at once, increasing the risk of side effects.

Dosage and Treatment

Your physician will determine the most suitable dosage based on your specific medical condition and how you respond to the medication. It is crucial to take Diethylpropion regularly and exactly as your physician prescribes. Consistency in timing is important for optimal results.

Managing Effectiveness

Over time, Diethylpropion may become less effective. If you find that the medication is no longer working well, consult your physician before adjusting the dosage. It is important to seek guidance from your physician before increasing or modifying the dosage.

Who Should Not Use Diethylpropion

It is important to note that Diethylpropion should not be used under certain medical conditions. Avoid using Diethylpropion if you have:

  • Heart problems or disease: Diethylpropion can potentially worsen existing heart conditions or pose risks to individuals with heart disease.
  • High blood pressure: Diethylpropion can increase blood pressure levels, which may be problematic for individuals with hypertension.
  • Hyperthyroidism: Diethylpropion can affect thyroid function and may adversely affect individuals with hyperthyroidism.
  • History of drug abuse: Individuals with a history of drug abuse or dependence should avoid using Diethylpropion, as it may lead to potential misuse or dependence issues.
  • Glaucoma: Diethylpropion can increase intraocular pressure, which can be harmful to individuals with glaucoma, a condition characterized by increased pressure within the eye.

Furthermore, Diethylpropion can interact with several medications, including but not limited to:

  • Blood pressure medications: Combining Diethylpropion with certain blood pressure medications can result in an increase in blood pressure or other unwanted effects. It is important to inform your doctor about all blood pressure medications you are taking.
  • Diabetes medications: Diethylpropion can potentially interact with insulin or oral diabetes medications, requiring adjustments to your diabetes treatment plan. Your doctor should be aware of all diabetes medications you are using.
  • Stimulants or ADHD medications: Concurrent use of Diethylpropion with other stimulants or medications used for attention deficit hyperactivity disorder (ADHD) can lead to an increase in stimulant effects and potential adverse reactions.
  • Antidepressants: Diethylpropion may interact with certain antidepressant medications, necessitating careful monitoring and potential dosage adjustments.

To ensure your safety and optimize treatment outcomes, it is crucial to inform your doctor about all the medications you are currently taking, including prescription medications, over-the-counter drugs, and any herbal supplements or dietary supplements.

By being aware of these contraindications and potential drug interactions, you can work together with your healthcare provider to make informed decisions and ensure the safe and effective use of Diethylpropion.


Like all prescription appetite suppressants, there are common side effects. Diethylpropion side effects can include:

  • trouble sleeping
  • dizziness 
  • tremors
  • increased sweating
  • hyperactivity or restlessness
  • upset stomach, nausea, or constipation
  • dry mouth
  • blurred vision
  • headache
  • irritability

Your doctor can tell you about other potential side effects. Additionally, you should be aware of certain side effects that your doctor will want you to contact about, including changes in mood, heart fluttering or pounding, changes in urination, or increased blood pressure. 

Work with TransformYou

Appetite suppressants should NOT be used as a substitute for proper diet or exercise. They must be used in conjunction with lifestyle modification, a reduced-calorie diet, and exercise for maximum effects. Any modifications in your diet, activity level, and behavior must be developed and continued long-term in order to continue losing weight and prevent the lost weight from returning. Transformyou will help you stay on track with your medical weight loss goals, checking in on you frequently regarding your general health, weight, etc., and adjusting your medical weight loss plan according to your needs.

All patients always work directly with one of our licensed physicians to ensure patient safety and confidentiality.

Learn more about medical weight loss

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Other appetite suppressants we offer:

The Controlled Substances Prescription Monitoring Program (CSPMP) is a program developed to promote the public health and welfare by detecting diversion, abuse and misuse of prescription medications classified as controlled substances under the Arizona Uniform Controlled Substances Act.  Every Physician who possesses a DEA registration is required to also possess a CSPMP registration issued by the Arizona Board of Pharmacy. At transformyou, we adhere to Arizona's CSPMP policy before prescribing a controlled substance to any patient.