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Timeline for Testosterone Injections to Work

Testosterone therapy is not a quick fix that will end or reverse all symptoms of low testosterone overnight, but that does not mean that someone will have to wait months and months before he or she starts to notice positive improvements in their life. How quickly testosterone injections work in the body is going to be subject to how each individual’s system responds to the hormone.

The Scientific Affairs team at Men's Healthcare in Germany recently asked that same question, and their results were quite interesting.

With testosterone replacement therapy, effects with sexual interest appear after three weeks, and plateau at six weeks, with no further increments expected beyond. Changes in erections/ejaculations may require up to 6 months of testosterone replacement therapy. Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer. Effects on depressive mood become detectable after 3-6 weeks with a maximum after 18-30 weeks. Effects on erythropoiesis (the process by which red blood cells are produced) are evident at three months, peaking at 9-12 months. Prostate-specific antigen and volume rise, marginally, plateauing at 12 months; further increase should be related to aging rather than testosterone replacement therapy. Effects on lipids appear after four weeks, maximal after 6-12 months. Insulin sensitivity may improve within few days, but effects on glycemic control become evident only after 3-12 months. Changes in fat mass, lean body mass, and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but can marginally continue over the years. Effects on inflammation occur within 3-12 weeks. Effects on bone are detectable already after six months while continuing for at least for three years. Read the full study here.

These results show that while the effectiveness time with testosterone replacement therapy varies from symptom to symptom, it does take only a short time to see improvements compared to dealing with the effects of low testosterone for a lifetime.

The information highlighted in this article is a guideline of what to expect but is not set in stone. Some people may experience certain results at a faster pace while others may find it takes a little longer to see positive changes. How quickly testosterone therapy works for each person is also, in part, dependent on the steps taken to assist the process by making subtle changes in one’s lifestyle. Getting proper sleep, eating well, and exercising will all help improve the effectiveness of testosterone treatment.

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